Extending Inferences from Randomized Participants to All Eligible Individuals Using Clinical Trials Nested Within Cohorts

Improving efficiency of inferences in randomized clinical trials using auxiliary covariates.

The primary goal of a randomized clinical trial is to make comparisons among two or more treatments. For example, in a two-arm trial with continuous response, the focus may be on the difference in treatment means; with more than two treatments, the comparison may be based on pairwise differences. With binary outcomes, pairwise odds ratios or log odds ratios may be used. In general, comparisons ...

Endovascular stroke trials: why we must enroll all eligible patients.

I s it appropriate to enroll into a clinical trial (and hence randomize to either medical or endovascular therapy) a 45-year-old patient who presents within 3 hours of onset of disabling symptoms resulting from a left M1 occlusion? This is the question many of us have faced in the course of the past few months because multiple new trials of endo-vascular stroke therapy have been launched on the...

Title : Recruiting Participants for Randomized Controlled Trials

Title Page Not included in page count. Title: Recruiting Participants for Randomized Controlled Trials Authors and Affiliations: H. Alix Gallagher, Jeremy Roschelle, Mingyu Feng, SRI International SREE Fall 2014 Conference Abstract Template

Short-term Outcomes of Infants Enrolled in Randomized Clinical Trials vs Those Eligible but Not Enrolled.

What proportion of chronic obstructive pulmonary disease outpatients is eligible for inclusion in randomized clinical trials?

BACKGROUND AND OBJECTIVE We aimed to explore to what extent an unselected population of chronic obstructive pulmonary disease (COPD) outpatients would be eligible for inclusion in randomized clinical trials (RCTs). METHODS Retrospective analysis of the clinical records of outpatient subjects with an ascertained diagnosis of COPD. COPD outpatients were assessed against the following inclusion ...